| Name | Pos | CFL Teams & Years |
| Dyton Blackett | LB | Hamilton (2023) |
| Gregor MacKellar | OL | Toronto (2022-present) |
| Jonathan Zamora | OL | Calgary (2022-present), Toronto (2021-2022) |
| Keiran Burnham | K/P | Calgary (2021-present) |
| Kaion Julien-Grant | WR | Montreal (2019-present) |
| Gordon Whyte | LB | Hamilton (2021-present) |
| Kay Okafor | DL | Hamilton (2018-present) |
| Ron Omara | LB | Hamilton (2015-2016), Ottawa (2017-2018) |
| Devon Bailey | WR | Edmonton (2014-2016), Saskatchewan (2017-2018) |
| Raye Hartmann | DB | Edmonton (2014-2015), Saskatchewan (2016-2017) |
| Terry Hart | OL | Saskatchewan (2015-2016) |
| Anthony Alix | K/P | Toronto (2012), Ottawa (2015), Toronto (2015) |
| Henoc Muamba | LB | Winnipeg (2010-2013), Indianapolis Colts (NFL, 2013-2015), Saskatchewan (2016-2017), Montreal (2015, 2018-2019), Toronto (2021-present) |
| Akeem Foster | WR | BC (2010-2013), Winnipeg (2013), Edmonton (2014) |
| Cauchy Muamba | DB | BC (2010-2012), Winnipeg (2013), Edmonton (2014-2017) |
| Corbin Sharun | DB | Edmonton (2010-2014), Calgary (2015-2016) |
| Steve Myddelton | DE | Calgary (2009-2012), Calgary/BC (2013), Hamilton/Edmonton (2014) |
| Jonathan Hood | DB | Hamilton (2010-12), Toronto (2013-2014) |
| Adam Kania | DE | Hamilton (2008) |
| Sean Manning | S | Calgary (2007-2008), Hamilton (2008-2009) |
| Derek Armstrong | OL | Calgary (2006-2009) |
| Jeremy Steeves | S | Hamilton (2005), Edmonton (2007) |
| Richard Karikari | CB | Montreal (2003-2006), Hamilton (2007), Calgary (2008) |
| Mike McCullough | LB | Saskatchewan (2003-2014) |
| Adam MacDonald | LB | Hamilton (2003) |
| Jacob Marini | K/P | Toronto (2000-2001) |
| Andre Arlain | SB | Calgary (1998-2000, 2003-2004), Winnipeg (2001-2002) |
| Mark (Farraway) Verbeek | DL | Edmonton (1997-1999), Hamilton (2000-2003) |
| Paul Frlan | LB | Saskatchewan (1997-1998) |
| Andrew McConnell | DL | Edmonton (1988-1990) |
| Dale Kinney | DE | Edmonton (1983) |
| Peter Martell | RB | Winnipeg (1981), Montreal (1982-1983) |
| Eugene Belliveau | DE | Montreal (1980-1984), Calgary (1985-1989) |
| Grant Stephenson | LB | Hamilton (1976) |
| Paul Brule | DB |
Winnipeg (1968-1971), Montreal (1972) |
| StFX X-Men Selected in CFL Draft | |||||
| Year | Overall | Round | Name | Pos | Drafting Team |
| 2023 | 55th | 7th | Alex Fedchun | DL | Ottawa |
| 2022 | 6th | 1st | Gregory MacKellar | OL | Calgary |
| 2022 | 56th | 7th | Connor Ross | TE | Ottawa |
| 2020 | 3rd | 26th | Jonathan Zamora | OL | Calgary |
| 2020 | 7th | 61st | Keiran Burnham | K/P | Calgary |
| 2019 | 13th | 2nd | Kaion Julien-Grant | WR | Montreal |
| 2019 | 67th | 8th | Gordon Whyte | LB | Hamilton |
| 2018 | 64th | 8th | Jacob Czaja | OL | Ottawa |
| 2017 | 21st | 3rd | Kay Okafor | DL | Hamilton |
| 2015 | 29th | 4th | Ron Omara | LB | Hamilton |
| 2014 | 6th | 1st | Devon Bailey | WR | Edmonton |
| 2014 | 30th | 4th | Raye Hartmann | DB | Edmonton |
| 2014 | 63rd | 7th | Terry Hart | OL | Saskatchewan |
| 2011 | 1st | 1st | Henoc Muamba | LB | Winnipeg |
| 2010 | 25th | 4th | Akeem Foster | WR | BC |
| 2010 | 34th | 5th | Cauchy Muamba | DB | BC |
| 2010 | 43rd | 6th | Corbin Sharun | DB | Edmonton |
| 2009 | 30th | 4th | Steve Myddelton | DE | Calgary |
| 2009 | 34th | 5th | Gordon Sawler | DL | Toronto |
| 2008 | 26th | 4th | Jonathan Hood | DB | Edmonton |
| 2007 | 42nd | 6th | Travis Noel | DB/DD | Winnipeg |
| 2007 | 43rd | 6th | Adam Kania | DE/AD | Hamilton |
| 2006 | 38th | 5th | Derek Armstrong | OL | Calgary |
| 2005 | 32nd | 4th | Jeremy Steeves | S | Hamilton |
| 2004 | 46th | 6th | Andrew Gallant | SB | Calgary |
| 2003 | 14th | 2nd | Richard Karikari | CB | Montreal |
| 2003 | 23rd | 3rd | Mike McCullough | LB | Saskatchewan |
| 1998 | 10th | 2nd | Andre Arlain | SB | Calgary |
| 1997 | 8th | 1st | Mark (Farraway) Verbeek | DL | Edmonton |
| 1996 | 29th | 4th | Paul Frlan | LB | Saskatchewan |
| 1996 | 33rd | 4th | Kevin Ho-Young | RB | BC |
| 1995 | 54th | 6th | Brad Fielding | DT | Calgary |
| 1990 | 54th | 7th | Maki Katsube | SB/RB | Edmonton |
| 1987 | 6th | 1st | Andrew McConnell | DL | Winnipeg |
| 1987 | 45th | 5th | Bill MacIntyre | WR | Hamilton |
| 1986 | 70th | 8th | Jadran Minarivic | K | Winnipeg |
| 1985 | 78th | 9th | Kevin Reaume | TE | Toronto |
| 1983 | 16th | 2nd | Dale Kinney | DE | Edmonton |
| 1983 | 53rd | 6th | Joey Tynes | RB | Toronto |
| 1981 | 61st | 7th | Peter Martell | RB | Winnipeg |
| 1980 | 23rd | 3rd | Eugene Belliveau | DE | Montreal |
| 1979 | 20th | 3rd | Kevin Aver | DB | BC |
| 1979 | 51st | 6th | Scott Spurgeon | DB | Ottawa |
| 1977 | 70th | 8th | Mark Dumont | LB | Hamilton |
| 1977 | 81st | 9th | Phil Ridley | FB | Ottawa |
| 1975 | 34th | 5th | Grant Stephenson | LB | Ottawa |
| 1972 | 28th | 4th | Jim Leone | G | Montreal |
| 1971 | 50th | 6th | Bill Hartley | G | Toronto |
| 1970 | 11th | 2nd | Burns McPherson | DB | Montreal |
| 1970 | 54th | 7th | Tony Arnason | FL | Montreal |
| 1969 | n/a | 7th | Terry Dolan | QB | Winnipeg |
| 1969 | n/a | 8th | Bryce Bell | T | Winnipeg |
| 1969 | n/a | 8th | Rick Alcock | HB | Hamilton |
| 1969 | n/a | 10th | John Keaveney | T | Saskatchewan |
| 1968 | n/a | 2nd | Jon Purcell | TE | Toronto |
| 1968 | n/a | 7th | Terry Gorman | DB | Toronto |
| 1968 | 4th | 1st | Paul Brule | HB | Ottawa |
| 1966 | n/a | 3rd | Tod Scott | FL | Ottawa |
| 1966 | n/a | 7th | Phil Hughes | OG | Ottawa |
| 1966 | n/a | 9th | Steve Connelly | T | Saskatchewan |
| 1964 | n/a | 2nd | John Shaw | TE | Toronto |
| 1964 | 36th | 4th | Joel LaMorre | TE | Ottawa |
| 1964 | 42nd | 5th | Jim Burke | T | Ottawa |
| 1963 | n/a | 5th | Neil Weber | HB | Toronto |
| 1963 | n/a | 10th | Jack Dineen | TE | Montreal |
History of StFX X-Men selected in the CFL DRAFT:
| BY ROUND | BY TEAM | |||
| 1st | 6 | BC | 4 | |
| 2nd | 7 | Calgary | 7 | |
| 3rd | 6 | Edmonton | 7 | |
| 4th | 10 | Hamilton | 8 | |
| 5th | 7 | Montreal | 7 | |
| 6th | 8 | Ottawa | 11 | |
| 7th | 10 | Saskatchewan | 5 | |
| 8th | 6 | Toronto | 9 | |
| 9th | 3 | Winnipeg | 7 | |
| 10th | 2 | |||
| TOTAL | 65 | |||